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2-(3-Methyl-3H-diazirin-3-yl)ethan-1-amine hydrochloride

  • CAS No. 25055-95-2

  • Cat. No. CS-0653829
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(3-Methyl-3H-diazirin-3-yl)ethan-1-amine hydrochloride|CS-0653829

Structure of 25055-95-2

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General Information

  • CAS No. 25055-95-2
  • Cat. No. CS-0653829
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀ClN₃
  • Molecular Weight 135.60
  • Synonym(s) 3-Methyl-3H-diazirine-3-ethanamine (hydrochloride)
  • SMILES NCCC1(C)N=N1.[H]Cl

Description

This bench-stable diazirine derivative features a reactive methyl-substituted diazirinyl group tethered to an ethylamine chain, enabling efficient photoaffinity labeling under UV irradiation. The hydrochloride salt enhances solubility and handling in aqueous biological systems, facilitating site-specific protein crosslinking and target identification in live-cell environments.

Application

2-(3-Methyl-3H-diazirin-3-yl)ethan-1-amine (hydrochloride) serves as a versatile photoaffinity labeling reagent, enabling site-specific covalent crosslinking upon UV irradiation. The diazirine moiety exhibits high stability under ambient conditions and reacts selectively with adjacent C–H and N–H bonds, facilitating the identification of protein-ligand interactions. Its amine functionality supports facile conjugation to biomolecules via standard coupling chemistries, while the hydrochloride salt enhances solubility and handling for aqueous-based applications.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅱ
Hazard Statements : H228-H315-H319
Precautionary Statements : P210-P240-P241-P264-P280-P302+P352-P362+P364-P370+P378

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Computational Chemistry Data

  • TPSA   50.74
  • LogP   0.939
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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