2-Chloro-5-fluoronicotinaldehyde

Name: 2-Chloro-5-fluoronicotinaldehyde
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CAS No. 851484-95-2
Cat. No. CS-0043904
Purity≥97%
MDL No.MFCD03095247

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Chloro-5-fluoronicotinaldehyde|CS-0043904

Structure of 851484-95-2

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General Information

CAS No. 851484-95-2
Cat. No. CS-0043904
Purity ≥97%
MDL No. MFCD03095247
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClFNO
Molecular Weight 159.55
Synonym(s) 3-pyridinecarboxaldehyde, 2-chloro-5-fluoro-
SMILES FC1=CN=C(Cl)C(C=O)=C1

Description

2-Chloro-5-fluoronicotinaldehyde features a highly reactive aldehyde group flanked by electron-withdrawing chlorine and fluorine substituents, enhancing electrophilicity for nucleophilic addition. This configuration enables efficient coupling in synthetic transformations, particularly in heterocyclic scaffold construction and pharmaceutical intermediates.

Application

2-Chloro-5-fluoronicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its dual halogenation pattern enhances reactivity in cross-coupling processes, while the aldehyde functionality facilitates imine formation and one-pot transformations. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 29.96
LogP 1.6866
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-fluoronicotinaldehyde

CAS No. 851484-95-2

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