2,6-Dichloro-5-fluoronicotinaldehyde

Name: 2,6-Dichloro-5-fluoronicotinaldehyde
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CAS No. 1260758-33-5
Cat. No. CS-0197795
Purity≥97%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2,6-Dichloro-5-fluoronicotinaldehyde|CS-0197795

Structure of 1260758-33-5

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General Information

CAS No. 1260758-33-5
Cat. No. CS-0197795
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂Cl₂FNO
Molecular Weight 193.99
Synonym(s) 2,6-Dichloro-5-fluoropyridine-3-carboxaldehyde
SMILES O=CC1=CC(F)=C(Cl)N=C1Cl

Description

2,6-Dichloro-5-fluoronicotinaldehyde features a highly electron-deficient pyridine core with orthogonal halogen substituents enabling selective cross-coupling. This bench-stable aldehyde integrates readily into complex heterocycles and serves as a key building block for pharmaceutical intermediates requiring enhanced metabolic stability.

Application

2,6-Dichloro-5-fluoronicotinaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via condensation reactions. Its electron-deficient pyridine core enhances reactivity in nucleophilic additions and facilitates coupling with amines, hydrazines, and other nitrogen-containing nucleophiles. The ortho-chloro substituents provide synthetic handles for further functionalization, while the aldehyde group offers direct access to imines, oximes, and related derivatives. Bench-stable and amenable to purification by distillation or chromatography, it functions reliably in multi-step syntheses requiring precise functional group control.

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

TPSA 29.96
LogP 2.34
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,6-Dichloro-5-fluoronicotinaldehyde

CAS No. 1260758-33-5

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