Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Ethyl 2,6-dichloro-5-fluoronicotinate

  • CAS No. 82671-03-2

  • Cat. No. CS-0169351
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 2,6-dichloro-5-fluoronicotinate|CS-0169351

Structure of 82671-03-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 82671-03-2
  • Cat. No. CS-0169351
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆Cl₂FNO₂
  • Molecular Weight 238.04
  • Synonym(s) Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate
  • SMILES O=C(OCC)C1=C(Cl)N=C(Cl)C(F)=C1

Description

Ethyl 2,6-dichloro-5-fluoronicotinate features a trifunctional heterocyclic core with strategically positioned electron-withdrawing chlorine and fluorine substituents. This configuration enhances reactivity in cross-coupling processes while maintaining stability under standard conditions. The ester group enables direct incorporation into complex molecular architectures without additional activation.

Application

Ethyl 2,6-dichloro-5-fluoronicotinate serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocyclic scaffolds via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its orthogonal halogen reactivity profile—combining chlorine for stable coupling and fluorine for directed functionalization—facilitates modular diversification. The ester functionality supports further transformations, while the compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthetic workflows.

Synthesis

  • Route1

    References

    • Abbott Laboratories Patent: US5250548 A1, 1993 ; US 5250548 A
  • Route2
    • null|null
      96568-02-4
    • ~95%
    • In-stock
      Ethyl 2,6-dichloro-5-fluoronicotinate|CS-0169351
      82671-03-2

    References

    • AstraZeneca AB Patent: US2008/171732 A1, 2008 ; Location in patent: Page/Page column 40 ; US 20080171732 A1
  • Route3
    • null|null
      64-17-5
    • null|null
      96568-02-4
    • ~92%
    • In-stock
      Ethyl 2,6-dichloro-5-fluoronicotinate|CS-0169351
      82671-03-2

    References

    • ASTRAZENECA AB Patent: WO2008/85119 A1, 2008 ; Location in patent: Page/Page column 209 ; WO 2008/085119 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.7042
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Ethyl 2,6-dichloro-5-fluoronicotinate sigmaEthyl 2,6-dichloro-5-fluoronicotinate manufacturerEthyl 2,6-dichloro-5-fluoronicotinate priceEthyl 2,6-dichloro-5-fluoronicotinate structureEthyl 2,6-dichloro-5-fluoronicotinate SDSbuy Ethyl 2,6-dichloro-5-fluoronicotinateEthyl 2,6-dichloro-5-fluoronicotinate supplierEthyl 2,6-dichloro-5-fluoronicotinate usesEthyl 2,6-dichloro-5-fluoronicotinate molecular weightprice of Ethyl 2,6-dichloro-5-fluoronicotinateEthyl 2,6-dichloro-5-fluoronicotinate chemical name formula of Ethyl 2,6-dichloro-5-fluoronicotinate
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label