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Structure of 154012-17-6
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Ethyl 4,6-dichloro-5-fluoronicotinate is a bench-stable, electron-deficient heterocyclic ester featuring orthogonal halogen handles. This trifunctional scaffold enables direct coupling in cross-coupling and C–H functionalization reactions, delivering access to fluorinated pyridine derivatives under standard conditions.
Ethyl 4,6-dichloro-5-fluoronicotinate serves as a versatile building block in heterocyclic synthesis, enabling the construction of fluorinated pyridine scaffolds relevant to medicinal chemistry. Its dual chloro substituents at C4 and C6 facilitate selective cross-coupling reactions, while the electron-withdrawing fluoro group enhances reactivity in nucleophilic substitution processes. The ester functionality provides a handle for downstream transformations, offering excellent bench stability and compatibility with standard purification methods.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: