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CS-W001157 4
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Ethyl 4,6-dichloro-5-fluoronicotinate

  • CAS No. 154012-17-6

  • Cat. No. CS-0151707
  • Purity≥97%
  • MDL No.MFCD18256592
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Ethyl 4,6-dichloro-5-fluoronicotinate|CS-0151707

Structure of 154012-17-6

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Description

Ethyl 4,6-dichloro-5-fluoronicotinate is a bench-stable, electron-deficient heterocyclic ester featuring orthogonal halogen handles. This trifunctional scaffold enables direct coupling in cross-coupling and C–H functionalization reactions, delivering access to fluorinated pyridine derivatives under standard conditions.

Application

Ethyl 4,6-dichloro-5-fluoronicotinate serves as a versatile building block in heterocyclic synthesis, enabling the construction of fluorinated pyridine scaffolds relevant to medicinal chemistry. Its dual chloro substituents at C4 and C6 facilitate selective cross-coupling reactions, while the electron-withdrawing fluoro group enhances reactivity in nucleophilic substitution processes. The ester functionality provides a handle for downstream transformations, offering excellent bench stability and compatibility with standard purification methods.

General Information

  • CAS No. 154012-17-6
  • Cat. No. CS-0151707
  • Purity ≥97%
  • MDL No. MFCD18256592
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆Cl₂FNO₂
  • Molecular Weight 238.04
  • Synonym(s) Ethyl 4,6-dichloro-5-fluoropyridine-3-carboxylate, 2,4-Dichloro-5-(ethoxycarbonyl)-3-fluoropyridine
  • SMILES CCOC(=O)C1=CN=C(C(=C1Cl)F)Cl

Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.7042
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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