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CS-W001157 4
Total: USD 88.00

3,5-Difluoro-4-(trifluoromethyl)phenyl boronic acid

  • CAS No. 1459778-94-9

  • Cat. No. CS-0178177
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,5-Difluoro-4-(trifluoromethyl)phenyl boronic acid|CS-0178177

Structure of 1459778-94-9

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General Information

  • CAS No. 1459778-94-9
  • Cat. No. CS-0178177
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BF₅O₂
  • Molecular Weight 225.91
  • Synonym(s) [3,5-Difluoro-4-(trifluoromethyl)phenyl]boronic acid
  • SMILES OB(C1=CC(F)=C(C(F)(F)F)C(F)=C1)O

Description

3,5-Difluoro-4-(trifluoromethyl)phenyl boronic acid features a trifluoromethyl group flanked by two fluorine substituents, delivering enhanced electron-withdrawing character and improved stability. This combination enables efficient Suzuki-Miyaura coupling under standard conditions, with robust performance in late-stage functionalization of heterocyclic scaffolds.

Application

3,5-Difluoro-4-(trifluoromethyl)phenyl boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its trifluoromethyl and difluoro substituents enhance metabolic stability and modulate electronic properties, making it valuable for constructing fluorinated aromatic scaffolds in pharmaceutical and agrochemical research. The boronic acid functionality offers excellent bench stability and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.6634
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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