6-Chloro-5-fluoronicotinaldehyde

Name: 6-Chloro-5-fluoronicotinaldehyde
Brand: ChemScene
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CAS No. 950691-52-8
Cat. No. CS-0045099
Purity≥97%
MDL No.MFCD13189060

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Chloro-5-fluoronicotinaldehyde|CS-0045099

Structure of 950691-52-8

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General Information

CAS No. 950691-52-8
Cat. No. CS-0045099
Purity ≥97%
MDL No. MFCD13189060
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClFNO
Molecular Weight 159.55
Synonym(s) 6-chloro-5-fluoropyridine-3-carbaldehyde
SMILES O=CC1=CN=C(Cl)C(F)=C1

Description

6-Chloro-5-fluoronicotinaldehyde features a highly reactive aldehyde group positioned ortho to electron-withdrawing chlorine and fluorine substituents, enhancing electrophilicity for nucleophilic addition reactions. This bench-stable scaffold integrates readily into heterocyclic synthesis, enabling efficient access to fluorinated pyridine derivatives with tailored electronic properties.

Application

6-Chloro-5-fluoronicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via condensation and coupling reactions. Its ortho-halogenated aldehyde functionality provides high reactivity for C–H functionalization, Suzuki-Miyaura coupling, and amide formation, with excellent bench stability and compatibility in multi-step synthesis.

Synthesis

Route1
- 1369256-86-9
- ~%
- In-stock
  
  950691-52-8
References
- WO2012/75917 A1, ; Page/Page column 31 ; WO 2012/075917 A1
Route2
- In-stock
  
  34552-15-3
- ~%
- In-stock
  
  950691-52-8
References
- WO2012/75917 A1, ; WO 2012/075917 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 29.96
LogP 1.6866
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-5-fluoronicotinaldehyde

CAS No. 950691-52-8

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