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CS-W001157 4
Total: USD 88.00

6-Chloro-5-fluoronicotinic acid

  • CAS No. 38186-86-6

  • Cat. No. CS-W000097
  • Purity≥98%
  • MDL No.MFCD11226507

*For research and further manufacturing use only, not for direct human use.

6-Chloro-5-fluoronicotinic acid|CS-W000097

Structure of 38186-86-6

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General Information

  • CAS No. 38186-86-6
  • Cat. No. CS-W000097
  • Purity ≥98%
  • MDL No. MFCD11226507
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClFNO₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES ClC1=C(F)C=C(C(O)=O)C=N1

Description

6-Chloro-5-fluoronicotinic acid features a highly electron-deficient pyridine core, enabling efficient coupling in cross-coupling reactions. The ortho-chloro and meta-fluoro substituents provide orthogonal reactivity for selective functionalization, while the carboxylic acid group facilitates direct conjugation or derivatization under standard conditions.

Application

6-Chloro-5-fluoronicotinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive heterocycles via standard coupling reactions. Its ortho-halogenated pyridine core facilitates palladium-catalyzed cross-couplings and nucleophilic aromatic substitution, while the carboxylic acid group allows for facile derivatization. Bench-stable and compatible with diverse functional groups, it functions as a key scaffold for developing pharmaceutical intermediates and agrochemicals.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5723
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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