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2-Chloro-3-fluoro-5-methylpyridine

  • CAS No. 34552-15-3

  • Cat. No. CS-D0946
  • Purity≥98%
  • MDL No.MFCD06658238

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-fluoro-5-methylpyridine|CS-D0946

Structure of 34552-15-3

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General Information

  • CAS No. 34552-15-3
  • Cat. No. CS-D0946
  • Purity ≥98%
  • MDL No. MFCD06658238
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClFN
  • Molecular Weight 145.56
  • Synonym(s) Pyridine, 2-chloro-3-fluoro-5-methyl-
  • SMILES CC1=CN=C(Cl)C(F)=C1

Description

2-Chloro-3-fluoro-5-methylpyridine is a halogenated pyridine derivative featuring complementary chlorine and fluorine substituents at adjacent positions, enabling selective functionalization in medicinal chemistry. The methyl group at the 5-position enhances lipophilicity and metabolic stability. This scaffold integrates readily into bioactive molecules through cross-coupling reactions and serves as a key building block for pharmaceutical intermediates requiring precise electronic tuning and steric control under standard conditions.

Application

2-Chloro-3-fluoro-5-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The strategically positioned chloro and fluoro groups facilitate sequential functionalization, while the methyl substituent enhances lipophilicity and metabolic stability. This compound exhibits bench stability and compatibility with standard reaction conditions, making it well-suited for the synthesis of heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
    • null|null
      99268-30-1
    • ~43%
    • In-stock
      2-Chloro-3-fluoro-5-methylpyridine|CS-D0946
      34552-15-3

    References

    • The Dow Chemical Company Patent: US4562009 A1, 1985 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.18252
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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