2-Chloro-3-fluoro-5-methylpyridine

Name: 2-Chloro-3-fluoro-5-methylpyridine
Brand: ChemScene
Availability: InStock
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CAS No. 34552-15-3
Cat. No. CS-D0946
Purity≥98%
MDL No.MFCD06658238

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-3-fluoro-5-methylpyridine|CS-D0946

Structure of 34552-15-3

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Description

2-Chloro-3-fluoro-5-methylpyridine is a halogenated pyridine derivative featuring complementary chlorine and fluorine substituents at adjacent positions, enabling selective functionalization in medicinal chemistry. The methyl group at the 5-position enhances lipophilicity and metabolic stability. This scaffold integrates readily into bioactive molecules through cross-coupling reactions and serves as a key building block for pharmaceutical intermediates requiring precise electronic tuning and steric control under standard conditions.

Application

2-Chloro-3-fluoro-5-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The strategically positioned chloro and fluoro groups facilitate sequential functionalization, while the methyl substituent enhances lipophilicity and metabolic stability. This compound exhibits bench stability and compatibility with standard reaction conditions, making it well-suited for the synthesis of heterocyclic scaffolds and API intermediates.

General Information

CAS No. 34552-15-3
Cat. No. CS-D0946
Purity ≥98%
MDL No. MFCD06658238
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClFN
Molecular Weight 145.56
Synonym(s) Pyridine, 2-chloro-3-fluoro-5-methyl-
SMILES CC1=CN=C(Cl)C(F)=C1

Computational Chemistry Data

TPSA 12.89
LogP 2.18252
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-3-fluoro-5-methylpyridine

CAS No. 34552-15-3

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