Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Benzyl 4-(bromomethyl)piperidine-1-carboxylate

  • CAS No. 159275-17-9

  • Cat. No. CS-W002953
  • Purity≥95%
  • MDL No.MFCD02681989

*For research and further manufacturing use only, not for direct human use.

Benzyl 4-(bromomethyl)piperidine-1-carboxylate|CS-W002953

Structure of 159275-17-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 159275-17-9
  • Cat. No. CS-W002953
  • Purity ≥95%
  • MDL No. MFCD02681989
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₈BrNO₂
  • Molecular Weight 312.20
  • Synonym(s) N-(Benzyloxycarbonyl)-4-(bromomethyl)piperidine
  • SMILES BrCC1CCN(C(OCC2=CC=CC=C2)=O)CC1

Description

Benzyl 4-(bromomethyl)piperidine-1-carboxylate features a reactive bromomethyl group enabling efficient alkylation and coupling reactions. This bench-stable, moisture-tolerant reagent integrates readily into synthetic sequences for bioactive molecule construction, particularly in medicinal chemistry applications requiring piperidine scaffolds.

Application

Benzyl 4-(bromomethyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient construction of piperidine-based scaffolds. The bromomethyl group facilitates nucleophilic substitution reactions, while the benzyl ester provides orthogonal protection and ease of removal under standard hydrogenolysis conditions. Its stability and compatibility with diverse functional groups make it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Hase, Yasunori; Uchida, Itsuo; Aisaka, Kazuo; Katoh, Susumu; Cho, Hidetsura Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3586 - 3604
  • Route2
    • Benzyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate|CS-0046829
      159275-16-8
    • ~%
    • In-stock
      Benzyl 4-(bromomethyl)piperidine-1-carboxylate|CS-W002953
      159275-17-9

    References

    • US5719303 A1, ;
  • Route3
    • null|null
      558-13-4
    • In-stock
      Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate|CS-W002888
      122860-33-7
    • ~%
    • In-stock
      Benzyl 4-(bromomethyl)piperidine-1-carboxylate|CS-W002953
      159275-17-9

    References

    • US6562828 B1, ; US 6562828 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   29.54
  • LogP   3.4301
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 159275-17-9 sigma159275-17-9 manufacturer159275-17-9 price159275-17-9 structure159275-17-9 SDSbuy 159275-17-9159275-17-9 supplier159275-17-9 uses159275-17-9 molecular weightprice of 159275-17-9159275-17-9 chemical name formula of 159275-17-9
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label