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CS-W001157 4
Total: USD 88.00

Thalidomide-5-NH2-CH2-COOH

  • CAS No. 2412056-27-8

  • Cat. No. CS-0371180
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Thalidomide-5-NH2-CH2-COOH|CS-0371180

Structure of 2412056-27-8

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General Information

  • CAS No. 2412056-27-8
  • Cat. No. CS-0371180
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₃N₃O₆
  • Molecular Weight 331.28
  • Synonym(s) None
  • SMILES O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=C(NCC(O)=O)C=C3)=O

Description

Thalidomide-5-NH₂-CH₂-COOH integrates a strategically positioned amino-methylcarboxylate handle at the 5-position of the phthalimide core. This functionalized derivative enables direct conjugation in bioconjugation workflows, leveraging its reactive terminal amine and carboxylic acid for site-specific attachment. Designed for targeted drug delivery and probe development, it maintains the scaffold’s inherent stability and solubility profile under physiological conditions.

Application

Thalidomide-5-NH₂-CH₂-COOH serves as a key functionalized intermediate for targeted derivatization in medicinal chemistry. The pendant amino and carboxyl groups enable facile conjugation and salt formation, enhancing solubility and enabling bioconjugate synthesis. Its stability under standard bench conditions supports reliable handling, while the preserved glutarimide core maintains intrinsic activity relevant to immunomodulatory and anti-angiogenic applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   132.88
  • LogP   -1.1136
  • H_Acceptors   9
  • H_Donors   3
  • Rotatable_Bonds   4

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