Thalidomide-5-O-CH2-COOH

Name: Thalidomide-5-O-CH2-COOH
Brand: ChemScene
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CAS No. 2467425-53-0
Cat. No. CS-0637358
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 2467425-53-0

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General Information

CAS No. 2467425-53-0
Cat. No. CS-0637358
Purity ≥96%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₁₂N₂O₇
Molecular Weight 332.26
Synonym(s) None
SMILES O=C(O)COC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1

Description

Thalidomide-5-O-CH2-COOH features a strategically positioned carboxymethyl ester at the 5-oxygen site, enhancing solubility and enabling bioorthogonal conjugation. This derivative retains the core phthalimide scaffold while introducing a reactive handle for peptide coupling or surface immobilization, facilitating targeted delivery applications in chemical biology and medicinal chemistry workflows.

Application

Thalidomide-5-O-CH₂-COOH serves as a functionalized derivative enabling targeted conjugation and prodrug strategies in medicinal chemistry. The pendant carboxylic acid group facilitates amide bond formation, esterification, or metal coordination, enhancing solubility and bioavailability. Its stability under standard reaction conditions supports reliable use in peptide coupling, antibody-drug conjugation, and scaffold diversification for immunomodulatory agents.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 130.08
LogP -0.8306
H_Acceptors 9
H_Donors 2
Rotatable_Bonds 4

Other Classifications

Life Science PROTAC Ligand-Linker Conjugate

Life Science Linker PROTAC Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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Thalidomide-5-O-CH2-COOH

CAS No. 2467425-53-0

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