Thalidomide-5-NH2-CH2-COOH

Name: Thalidomide-5-NH2-CH2-COOH
Brand: ChemScene
Availability: InStock
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CAS No. 2412056-27-8
Cat. No. CS-0371180
Purity≥96%
MDL No.None

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 2412056-27-8

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Description

Thalidomide-5-NH₂-CH₂-COOH integrates a strategically positioned amino-methylcarboxylate handle at the 5-position of the phthalimide core. This functionalized derivative enables direct conjugation in bioconjugation workflows, leveraging its reactive terminal amine and carboxylic acid for site-specific attachment. Designed for targeted drug delivery and probe development, it maintains the scaffold’s inherent stability and solubility profile under physiological conditions.

Application

Thalidomide-5-NH₂-CH₂-COOH serves as a key functionalized intermediate for targeted derivatization in medicinal chemistry. The pendant amino and carboxyl groups enable facile conjugation and salt formation, enhancing solubility and enabling bioconjugate synthesis. Its stability under standard bench conditions supports reliable handling, while the preserved glutarimide core maintains intrinsic activity relevant to immunomodulatory and anti-angiogenic applications.

General Information

CAS No. 2412056-27-8
Cat. No. CS-0371180
Purity ≥96%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₁₃N₃O₆
Molecular Weight 331.28
Synonym(s) None
SMILES O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=C(NCC(O)=O)C=C3)=O

Computational Chemistry Data

TPSA 132.88
LogP -1.1136
H_Acceptors 9
H_Donors 3
Rotatable_Bonds 4

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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Thalidomide-5-NH2-CH2-COOH

CAS No. 2412056-27-8

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