Thalidomide-5-CH2-NH2 hydrochloride

Name: Thalidomide-5-CH2-NH2 hydrochloride
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CAS No. 1010100-22-7
Cat. No. CS-0187989
Purity≥98%
MDL No.MFCD32666042

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Thalidomide-5-CH2-NH2 hydrochloride|CS-0187989

Structure of 1010100-22-7

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General Information

CAS No. 1010100-22-7
Cat. No. CS-0187989
Purity ≥98%
MDL No. MFCD32666042
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₁₄ClN₃O₄
Molecular Weight 323.73
Synonym(s) None
SMILES NCC1=CC(C(N(C2C(NC(CC2)=O)=O)C3=O)=O)=C3C=C1.Cl

Description

Thalidomide-5-CH2-NH2 (hydrochloride) features a primary amine handle at the 5-position, enabling site-specific conjugation in bioconjugate applications. This derivative maintains the core thalidomide scaffold while enhancing solubility and reactivity under physiological conditions. The hydrochloride salt improves stability and handling for bench-scale synthesis and medicinal chemistry workflows.

Application

Thalidomide-5-CH₂-NH₂ (hydrochloride) serves as a functionalized derivative of thalidomide, enabling targeted conjugation and scaffold modification in medicinal chemistry. The primary amine group facilitates efficient coupling reactions, while the hydrochloride salt enhances solubility and stability for handling. This compound functions as a key building block in the synthesis of analogs for targeted protein degradation and immunomodulatory drug discovery.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 109.57
LogP -0.0317
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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Thalidomide-5-CH2-NH2 hydrochloride

CAS No. 1010100-22-7

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