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CS-W001157 4
Total: USD 88.00

L-Propargylglycine

  • CAS No. 23235-01-0

  • Cat. No. CS-W006064
  • Purity≥97%
  • MDL No.MFCD00077855

*For research and further manufacturing use only, not for direct human use.

L-Propargylglycine|CS-W006064

Structure of 23235-01-0

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General Information

  • CAS No. 23235-01-0
  • Cat. No. CS-W006064
  • Purity ≥97%
  • MDL No. MFCD00077855
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇NO₂
  • Molecular Weight 113.11
  • Synonym(s) (S)-2-Aminopent-4-ynoic acid
  • SMILES C#CC[C@H](N)C(O)=O

Description

Inhibiting cystathionine γ-lyase activity, L-C-Propargylglycine (CAS 23235-01-0) suppresses hydrogen sulfide biosynthesis in mammalian cell models.

Application

L-C-Propargylglycine (CAS 23235-01-0) irreversibly inactivates γ-cystathionase by covalently modifying its active site, enabling precise enzyme knockout studies in sulfur metabolism pathways. This reagent acts as a potent affinity label for γ-cystathionase and related enzymes. Researchers use it to tag active sites for structural analysis and to generate tritiated peptides with exceptional specific radioactivity.

Synthesis

  • Route1
    • null|null
      23235-02-1
    • ~91%
    • In-stock
      L-Propargylglycine|CS-W006064
      23235-01-0

    References

    • Cheung, Kam Sing; Wasserman, Steven A.; Dudek, Edward; Lerner, Stephen A.; Johnston, Michael Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1733 - 1741
  • Route2
    • null|null
      23235-02-1
    • ~86%
    • In-stock
      L-Propargylglycine|CS-W006064
      23235-01-0
    • In-stock
      L-Propargylglycine|CS-W006064
      23235-01-0

    References

    • Cheung, Kam Sing; Wasserman, Steven A.; Dudek, Edward; Lerner, Stephen A.; Johnston, Michael Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1733 - 1741
  • Route3
    • null|null
      212139-50-9
    • ~%
    • In-stock
      L-Propargylglycine|CS-W006064
      23235-01-0

    References

    • Tetrahedron Asymmetry, , vol. 9, # 11 p. 1967 - 1977

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   -0.5784
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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