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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-bromophenyl)propanoic acid

  • CAS No. 220497-48-3

  • Cat. No. CS-0101112
  • Purity≥95%
  • MDL No.MFCD01311744

*For research and further manufacturing use only, not for direct human use.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-bromophenyl)propanoic acid|CS-0101112

Structure of 220497-48-3

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General Information

  • CAS No. 220497-48-3
  • Cat. No. CS-0101112
  • Purity ≥95%
  • MDL No. MFCD01311744
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₀BrNO₄
  • Molecular Weight 466.32
  • Synonym(s) Fmoc-3-bromo-L-phenylalanine
  • SMILES O=C(O)[C@H](CC1=CC=CC(Br)=C1)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Description

This fluorenylmethoxycarbonyl-protected amino acid derivative features a chiral (S)-configuration and incorporates a brominated phenyl group at the beta position. The Cbz moiety ensures stability during peptide synthesis, while the para-bromophenyl side chain provides a handle for downstream functionalization via cross-coupling reactions.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-bromophenyl)propanoic acid serves as a robust chiral building block for peptide synthesis, offering high stereochemical integrity and facile removal of the Fmoc protecting group under mild basic conditions. The pendant bromophenyl moiety enables subsequent functionalization via cross-coupling reactions, while the Fmoc group ensures excellent bench stability and compatibility with standard solid-phase protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   4.9835
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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