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CS-W001157 4
Total: USD 88.00

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)amino)pentanoic acid

  • CAS No. 143824-77-5

  • Cat. No. CS-0101109
  • Purity≥95%
  • MDL No.MFCD00151918

*For research and further manufacturing use only, not for direct human use.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)amino)pentanoic acid|CS-0101109

Structure of 143824-77-5

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General Information

  • CAS No. 143824-77-5
  • Cat. No. CS-0101109
  • Purity ≥95%
  • MDL No. MFCD00151918
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₁H₄₀N₄O₈
  • Molecular Weight 596.67
  • Synonym(s) N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-N~5~-(2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)-L-ornithine
  • SMILES O=C(N[C@@H](CCC/N=C(NC(OC(C)(C)C)=O)\NC(OC(C)(C)C)=O)C(O)=O)OCC1C2=C(C3=C1C=CC=C3)C=CC=C2

Description

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)amino)pentanoic acid features a sterically hindered, moisture-tolerant diazadecane scaffold that enables robust coupling in peptide synthesis. The fluorenylmethoxycarbonyl (Fmoc) group ensures efficient N-terminal protection, while the electron-deficient amide linkage enhances lability during deprotection. This design supports high-yield chain elongation under standard conditions.

Synthesis

  • Route1
    • null|null
      102774-86-7
    • In-stock
      (S)-2-Amino-5-((2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)amino)pentanoic acid|CS-0698599
      145315-38-4
    • ~83%
    • In-stock
      (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)amino)pentanoic acid|CS-0101109
      143824-77-5

    References

    • Schaschke, Norbert Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 4 p. 855 - 857
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 4 p. 855 - 857
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 4 p. 855 - 857

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   164.65
  • LogP   5.1639
  • H_Acceptors   8
  • H_Donors   4
  • Rotatable_Bonds   8

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