Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyanopropanoic acid

  • CAS No. 127273-06-7

  • Cat. No. CS-0102038
  • Purity≥98%
  • MDL No.MFCD01861370

*For research and further manufacturing use only, not for direct human use.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyanopropanoic acid|CS-0102038

Structure of 127273-06-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 127273-06-7
  • Cat. No. CS-0102038
  • Purity ≥98%
  • MDL No. MFCD01861370
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₆N₂O₄
  • Molecular Weight 336.34
  • Synonym(s) Fmoc-beta-cyano-L-alanine
  • SMILES O=C(O)[C@H](CC#N)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyanopropanoic acid features a chiral center at the α-position, enabling stereoselective peptide synthesis. The fluorenylmethyl carbamate (Fmoc) group ensures efficient protection and orthogonal deprotection under mild conditions. This derivative integrates seamlessly into solid-phase workflows, delivering high coupling efficiency with minimal racemization.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyanopropanoic acid serves as a robust chiral building block for peptide synthesis, enabling efficient incorporation of β-aminonitrile motifs. The Fmoc group provides orthogonal protection and facilitates purification, while the nitrile functionality offers a versatile handle for downstream transformations including hydrolysis to carboxylic acids or conversion to amides. Bench-stable and compatible with standard coupling protocols, it functions reliably in solid-phase and solution-phase syntheses.

Synthesis

  • Route1

    References

    • Manturewicz; Grzonka Polish Journal of Chemistry, 2007 , vol. 81, # 12 p. 2121 - 2131

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   99.42
  • LogP   2.89198
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   5

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 127273-06-7 sigma127273-06-7 manufacturer127273-06-7 price127273-06-7 structure127273-06-7 SDSbuy 127273-06-7127273-06-7 supplier127273-06-7 uses127273-06-7 molecular weightprice of 127273-06-7127273-06-7 chemical name formula of 127273-06-7
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label