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CS-W001157 4
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(R)-3-(3-Bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

  • CAS No. 261360-77-4

  • Cat. No. CS-0043624
  • Purity≥98%
  • MDL No.MFCD01317704

*For research and further manufacturing use only, not for direct human use.

(R)-3-(3-Bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid|CS-0043624

Structure of 261360-77-4

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General Information

  • CAS No. 261360-77-4
  • Cat. No. CS-0043624
  • Purity ≥98%
  • MDL No. MFCD01317704
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₈BrNO₄
  • Molecular Weight 344.20
  • Synonym(s) None
  • SMILES O=C(O)[C@@H](CC1=CC=CC(Br)=C1)NC(OC(C)(C)C)=O

Description

(R)-3-(3-Bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid is a chiral building block featuring a brominated aromatic ring and a protected amino group. This configuration enables direct incorporation into peptide synthesis workflows, where the tert-butyl carbamate moiety provides orthogonal stability. The para-substituted aryl handle facilitates downstream functionalization via cross-coupling reactions.

Application

(R)-3-(3-Bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid serves as a valuable chiral building block for the synthesis of bioactive molecules, enabling efficient access to substituted phenylalanine derivatives. The Boc-protected amine offers excellent stability and orthogonal functionality, facilitating subsequent deprotection and coupling reactions. Its brominated aryl group supports diverse cross-coupling transformations, making it ideal for constructing complex scaffolds in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   2.9695
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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