Fmoc-Phe(3,5-DiF)-OH

Name: Fmoc-Phe(3,5-DiF)-OH
Brand: ChemScene
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CAS No. 205526-24-5
Cat. No. CS-W011643
Purity≥97%
MDL No.MFCD00797579

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 205526-24-5
Cat. No. CS-W011643
Purity ≥97%
MDL No. MFCD00797579
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₁₉F₂NO₄
Molecular Weight 423.41
Synonym(s) None
SMILES O=C(O)[C@H](CC1=CC(F)=CC(F)=C1)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Description

Fmoc-Phe(3,5-DiF)-OH features a fluorinated phenylalanine derivative with electron-withdrawing difluorophenyl substitution at the meta and para positions. This modification enhances metabolic stability and modulates electronic properties for use in peptide synthesis. The Fmoc group enables efficient N-terminal protection, while the sterically unhindered side chain supports high coupling yields under standard conditions.

Application

Fmoc-Phe(3,5-DiF)-OH serves as a valuable building block in peptide synthesis, offering enhanced metabolic stability and modulated electronic properties through its 3,5-difluorophenyl side chain. The fluorinated aromatic ring improves lipophilicity and resistance to oxidative degradation, while the Fmoc group enables efficient orthogonal protection for N-terminal control. This derivative facilitates robust coupling reactions and is well-suited for solid-phase and solution-phase workflows, particularly in the development of bioactive peptides requiring improved pharmacokinetic profiles.

Safety Information

Download SDS

GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H413
Precautionary Statements : P270-P501

Quality Control

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Computational Chemistry Data

TPSA 75.63
LogP 4.4992
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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Fmoc-Phe(3,5-DiF)-OH

CAS No. 205526-24-5

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