Lot numbers can be found on the outside label of a product:
N-Boc-L-3,5-difluorophenylalanine
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CAS No. 205445-52-9
- Cat. No. CS-0093741
- Purity≥97%
- MDL No.MFCD00797555
*For research and further manufacturing use only, not for direct human use.
Structure of 205445-52-9
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General Information
- CAS No. 205445-52-9
- Cat. No. CS-0093741
- Purity ≥97%
- MDL No. MFCD00797555
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₄H₁₇F₂NO₄
- Molecular Weight 301.29
- Synonym(s) None
- SMILES O=C(O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC(F)=CC(F)=C1
Description
N-Boc-L-3,5-difluorophenylalanine features a sterically hindered, electron-deficient aromatic ring that enhances metabolic stability in peptide sequences. The Boc group provides convenient protection for amine-directed coupling reactions, enabling straightforward incorporation into complex peptidomimetics under standard conditions.
Application
N-Boc-L-3,5-difluorophenylalanine serves as a stable, bench-ready building block for the synthesis of fluorinated peptide analogs and bioactive heterocycles. The Boc group provides orthogonal protection for the amine, enabling selective deprotection during peptide coupling. The 3,5-difluoro substitution enhances metabolic stability and modulates electronic properties, facilitating incorporation into drug-like scaffolds via standard amide bond formation and solid-phase synthesis protocols.
Synthesis
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Route1
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141776-91-2 - ~%
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In-stock
205445-52-9
References
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Tetrahedron Letters, , vol. 41, # 6 p. 923 - 927
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Route2
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266360-52-5 - ~%
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In-stock
205445-52-9
References
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Tetrahedron Letters, , vol. 41, # 6 p. 923 - 927
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Route3
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266360-46-7
- ~%
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In-stock
205445-52-9
References
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Tetrahedron Letters, , vol. 41, # 6 p. 923 - 927
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 75.63
- LogP 2.4852
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 4
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Key Words
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