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CS-W001157 4
Total: USD 88.00

Fmoc-D-Phe(3-F)-OH

  • CAS No. 198545-72-1

  • Cat. No. CS-W009713
  • Purity≥98%
  • MDL No.MFCD00672554

*For research and further manufacturing use only, not for direct human use.

Fmoc-D-Phe(3-F)-OH|CS-W009713

Structure of 198545-72-1

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General Information

  • CAS No. 198545-72-1
  • Cat. No. CS-W009713
  • Purity ≥98%
  • MDL No. MFCD00672554
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₀FNO₄
  • Molecular Weight 405.42
  • Synonym(s) None
  • SMILES O=C([C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)CC4=CC=CC(F)=C4)O

Description

Fmoc-D-Phe(3-F)-OH features a fluorinated phenyl ring at the meta position, enhancing electron-withdrawing character and metabolic stability. This derivative integrates readily into peptide chains under standard coupling conditions, offering improved solubility and reduced aggregation during synthesis. The Fmoc group enables efficient N-terminal protection and stepwise elongation in solid-phase peptide synthesis.

Application

Fmoc-D-Phe(3-F)-OH serves as a valuable building block in peptide synthesis, offering enhanced metabolic stability and modulated hydrophobicity through the meta-fluorinated phenyl side chain. The Fmoc group enables efficient N-terminal protection for solid-phase peptide synthesis, while the D-configuration imparts resistance to enzymatic degradation. This derivative facilitates the incorporation of fluorinated aromatic residues into bioactive peptides with improved membrane permeability and target binding affinity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   4.3601
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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