Lot numbers can be found on the outside label of a product:
H-Phe(3-F)-OH
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CAS No. 19883-77-3
- Cat. No. CS-0011429
- Purity≥97%
- MDL No.MFCD00066450
*For research and further manufacturing use only, not for direct human use.
Structure of 19883-77-3
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General Information
- CAS No. 19883-77-3
- Cat. No. CS-0011429
- Purity ≥97%
- MDL No. MFCD00066450
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₀FNO₂
- Molecular Weight 183.18
- Synonym(s) 3-Fluoro-L-phenylalanine; L-3-Fluorophenylalanine; m-Fluoro-L-phenylalanine; H-m-Fluoro-Phe-OH; H-Phe(3-F)-OH
- SMILES FC1=CC(C[C@H](N)C(O)=O)=CC=C1
Description
H-Phe(3-F)-OH is a fluorinated phenylalanine derivative featuring a meta-fluoro substitution on the aromatic ring. This electron-withdrawing group enhances metabolic stability and modulates binding affinity in peptide-based applications. The hydroxyl terminus enables straightforward conjugation or further functionalization, making it valuable for bioconjugation and peptidomimetic design.
Application
H-Phe(3-F)-OH serves as a valuable building block for the synthesis of bioactive peptides and pharmaceutical intermediates. The meta-fluorophenylalanine residue enhances metabolic stability and modulates electronic properties, enabling improved receptor binding affinity in peptide-based drug candidates. Its bench-stable, crystalline nature facilitates straightforward handling and purification, while maintaining compatibility with standard solid-phase peptide synthesis protocols.
Synthesis
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Route1
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In-stock
1866-38-2 - ~59%
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In-stock
19883-77-3
References
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Gloge, Andreas; Zon, Jerzy; Koevari, Agnes; Poppe, Laszlo; Retey, Janos Chemistry - A European Journal, 2000 , vol. 6, # 18 p. 3386 - 3390
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Route2
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56-40-6 -
456-41-7 - ~%
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In-stock
19883-77-3
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In-stock
110117-84-5
References
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Angewandte Chemie - International Edition, , vol. 40, # 10 p. 1948 - 1951
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References
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Tetrahedron, , vol. 61, # 43 p. 10254 - 10261
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 63.32
- LogP 0.7801
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 3
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Key Words
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