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tert-Butyl (3R)-3-(methylamino)piperidine-1-carboxylate

  • CAS No. 203941-94-0

  • Cat. No. CS-0048581
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (3R)-3-(methylamino)piperidine-1-carboxylate|CS-0048581

Structure of 203941-94-0

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General Information

  • CAS No. 203941-94-0
  • Cat. No. CS-0048581
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) R-N-Boc-3-methylamino piperidine
  • SMILES CN[C@@H]1CCCN(C1)C(=O)OC(C)(C)C

Description

tert-Butyl (3R)-3-(methylamino)piperidine-1-carboxylate features a chiral piperidine core with a methylamino substituent at the 3-position, delivering high stereochemical fidelity. This bench-stable, moisture-tolerant building block integrates readily into medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors.

Application

tert-Butyl (3R)-3-(methylamino)piperidine-1-carboxylate serves as a stereochemically defined building block for the synthesis of bioactive piperidine derivatives. Its tert-butyl carbamate group enables stable handling and facile deprotection under mild acidic conditions. The (3R)-configured piperidine core, bearing a methylamino substituent at C3, facilitates direct incorporation into diverse pharmaceutical scaffolds, particularly those requiring controlled stereoelectronic properties in medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6053
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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