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CS-W001157 4
Total: USD 88.00

(S)-3-N-Boc-3-(Methylamino)piperidine

  • CAS No. 309962-63-8

  • Cat. No. CS-B0444
  • Molecule weight214.30
  • Purity≥97%
  • MDL No.MFCD09878597

*For research and further manufacturing use only, not for direct human use.

(S)-3-N-Boc-3-(Methylamino)piperidine|CS-B0444

Structure of 309962-63-8

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General Information

  • CAS No. 309962-63-8
  • Cat. No. CS-B0444
  • Purity ≥97%
  • MDL No. MFCD09878597
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) (S)-tert-Butyl methyl(piperidin-3-yl)carbamate
  • SMILES O=C(OC(C)(C)C)N(C)[C@@H]1CNCCC1

Description

(S)-3-N-Boc-3-(Methylamino)piperidine features a chiral piperidine core with a Boc-protected amine and a methylamino substituent, enabling direct incorporation into complex molecular architectures. This bench-stable derivative facilitates efficient access to bioactive amines in medicinal chemistry campaigns.

Application

(S)-3-N-Boc-3-(Methylamino)piperidine serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to bioactive piperidine derivatives. The Boc-protected amine offers excellent bench stability and compatibility with standard coupling reactions, while the tertiary methylamino group provides a defined nitrogen handle for further functionalization. Its stereochemical purity facilitates reproducible synthesis of targeted scaffolds in API development workflows.

Synthesis

  • Route1
    • null|null
      309962-62-7
    • null|null
      74-88-4
    • ~90%
    • In-stock
      (S)-3-N-Boc-3-(Methylamino)piperidine|CS-B0444
      309962-63-8

    References

    • ABBOTT LABORATORIES Patent: EP1428824 A1, 2004 ; Location in patent: Page 45 ;
  • Route2
    • null|null
      1124199-24-1
    • ~%
    • In-stock
      (S)-3-N-Boc-3-(Methylamino)piperidine|CS-B0444
      309962-63-8

    References

    • WO2012/58645 A1, ; Page/Page column 135 ; WO 2012/058645 A1
  • Route3
    • tert-Butyl (S)-piperidin-3-ylcarbamate Linagliptin impurity|CS-1311968
      216854-23-8
    • ~%
    • In-stock
      (S)-3-N-Boc-3-(Methylamino)piperidine|CS-B0444
      309962-63-8

    References

    • WO2012/58645 A1, ; WO 2012/058645 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6053
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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