1-Boc-3-methylaminopieridine

Name: 1-Boc-3-methylaminopieridine
Brand: ChemScene
Availability: InStock
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CAS No. 392331-89-4
Cat. No. CS-0001873
Purity≥97%
MDL No.MFCD04114980

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 392331-89-4

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General Information

CAS No. 392331-89-4
Cat. No. CS-0001873
Purity ≥97%
MDL No. MFCD04114980
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₂N₂O₂
Molecular Weight 214.30
Synonym(s) tert-Butyl 3-(methylamino)piperidine-1-carboxylate
SMILES O=C(OC(C)(C)C)N(CCC1)CC1NC

Description

1-Boc-3-methylaminopieridine features a protected amine group at the 3-position of a pyridine core, enabling stable incorporation into multistep syntheses. The Boc moiety provides orthogonal protection for nitrogen functionalities, allowing selective deprotection under mild acidic conditions. This compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active molecules.

Application

1-Boc-3-methylaminopiperidine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted piperidine scaffolds. The Boc-protected amine ensures stability and ease of purification, while the pendant methylamino group provides a handle for further functionalization. It functions reliably in standard coupling, reduction, and cyclization reactions, supporting scalable synthesis of bioactive molecules.

Synthesis

Route1
- 1365161-09-6
- ~%
- In-stock
  
  392331-89-4
References
- US2006/100426 A1, ; Page/Page column 17 ; US 20060100426 A1
Route2
- 1027345-51-2
- ~%
- In-stock
  
  392331-89-4
References
- Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 1 p. 336 - 343

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06,GHS09
Signal Word : Danger	UN#: 2810
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335-H400
Precautionary Statements : P273-P302+P352-P330

Quality Control

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Computational Chemistry Data

TPSA 41.57
LogP 1.6053
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1-Boc-3-methylaminopieridine

CAS No. 392331-89-4

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