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CS-W001157 4
Total: USD 88.00

4-[(Piperidin-4-yl)oxy]piperidine-1-carboxylic acid tert-butyl ester

  • CAS No. 845305-83-1

  • Cat. No. CS-B1795
  • Purity≥95%
  • MDL No.MFCD09261176

*For research and further manufacturing use only, not for direct human use.

4-[(Piperidin-4-yl)oxy]piperidine-1-carboxylic acid tert-butyl ester|CS-B1795

Structure of 845305-83-1

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General Information

  • CAS No. 845305-83-1
  • Cat. No. CS-B1795
  • Purity ≥95%
  • MDL No. MFCD09261176
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₈N₂O₃
  • Molecular Weight 284.40
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(OC2CCNCC2)CC1

Description

This piperidine-based scaffold features a tethered tert-butyl ester and a pendant piperidin-4-ol moiety, enabling straightforward deprotection and functionalization. The molecule combines enhanced solubility with robust stability under standard bench conditions, facilitating efficient integration into medicinal chemistry campaigns targeting CNS-directed therapeutics.

Application

4-[(Piperidin-4-yl)oxy]piperidine-1-carboxylic acid tert-butyl ester serves as a versatile bifunctional building block for medicinal chemistry, enabling the construction of complex piperidine-containing scaffolds. The tert-butyl ester group provides bench stability and facilitates straightforward deprotection under mild acidic conditions. The ether-linked piperidine moiety offers orthogonal reactivity, supporting diverse functionalization strategies in API development workflows.

Synthesis

  • Route1
    • Tert-butyl 4-(pyridin-4-yloxy)piperidine-1-carboxylate|CS-0450848
      308386-35-8
    • ~59%
    • In-stock
      4-[(Piperidin-4-yl)oxy]piperidine-1-carboxylic acid tert-butyl ester|CS-B1795
      845305-83-1

    References

    • SCHERING CORPORATION Patent: WO2009/45313 A2, 2009 ; Location in patent: Page/Page column 43-44 ; WO 2009/045313 A2
  • Route2
    • 1-Benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide|CS-0971416
      845305-82-0
    • ~%
    • In-stock
      4-[(Piperidin-4-yl)oxy]piperidine-1-carboxylic acid tert-butyl ester|CS-B1795
      845305-83-1

    References

    • GLAXO GROUP LIMITED Patent: WO2005/14571 A1, 2005 ; Location in patent: Page/Page column 18-19 ; WO 2005/014571 A1
  • Route3
    • null|null
      1172626-94-6
    • ~72%
    • In-stock
      4-[(Piperidin-4-yl)oxy]piperidine-1-carboxylic acid tert-butyl ester|CS-B1795
      845305-83-1

    References

    • Bailey, James M.; Bruton, Gordon; Huxley, Anthony; Johnstone, Vicky; Milner, Peter H.; Orlek, Barry S.; Stemp, Geoffrey Synlett, 2009 , # 7 p. 1051 - 1054

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.8
  • LogP   2.1545
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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