Fmoc-Asp-NH2

Name: Fmoc-Asp-NH2
Brand: ChemScene
Availability: InStock
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CAS No. 200335-40-6
Cat. No. CS-0112610
Purity≥95%
MDL No.MFCD00151920

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 200335-40-6

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Description

Fmoc-Asp-NH2 is a protected aspartic acid derivative featuring a fluorenylmethoxycarbonyl group at the α-amino terminus and a free carboxylic acid at the side chain. This configuration enables direct incorporation into solid-phase peptide synthesis workflows, where the side-chain protection remains stable under standard deprotection conditions. The Fmoc moiety facilitates efficient coupling and selective removal via mild base treatment, streamlining sequence assembly.

Application

Fmoc-Asp-NH2 serves as a key building block in solid-phase peptide synthesis, offering orthogonal protection for both the α-amino and side-chain carboxyl groups. The Fmoc group enables mild base-labile deprotection, while the side-chain is protected as a stable tert-butyl ester, facilitating selective functionalization. Its bench-stable, crystalline form simplifies handling and purification, making it ideal for synthesizing complex peptides, including those containing acidic residues or requiring precise sequence control.

General Information

CAS No. 200335-40-6
Cat. No. CS-0112610
Purity ≥95%
MDL No. MFCD00151920
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₉H₁₈N₂O₅
Molecular Weight 354.36
Synonym(s) None
SMILES O=C(O)C[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(N)=O

Computational Chemistry Data

TPSA 118.72
LogP 1.8537
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker Cleavable Linkers

Life Science Linker Fmoc PEG

Life Science Linker Peptide Linkers

Life Science ADC Related Compound Cleavable Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

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Fmoc-Asp-NH2

CAS No. 200335-40-6

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