(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-allothreonine

Name: (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-allothreonine
Brand: ChemScene
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CAS No. 146306-75-4
Cat. No. CS-0100980
Purity≥98%
MDL No.MFCD01318739

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-allothreonine|CS-0100980

Structure of 146306-75-4

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Description

Fmoc-L-allothreonine is a protected amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) group for orthogonal protection in peptide synthesis. This configuration enables efficient N-terminal capping and facilitates purification via standard solid-phase protocols. The allothreonine side chain offers distinct stereochemical properties, enhancing structural diversity in bioactive peptide libraries.

Application

Boc-L-allothreonine, a key chiral building block in peptide synthesis, features a sterically hindered side chain and orthogonal protection for the hydroxyl group. It facilitates efficient solid-phase and solution-phase coupling reactions with excellent functional group tolerance and stability under standard deprotection conditions. The fluorenylmethoxycarbonyl (Fmoc) variant enables sequential addition in automated synthesis while maintaining high diastereoselectivity and purity.

General Information

CAS No. 146306-75-4
Cat. No. CS-0100980
Purity ≥98%
MDL No. MFCD01318739
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₉H₁₉NO₅
Molecular Weight 341.36
Synonym(s) None
SMILES C[C@H](O)[C@@H](C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Computational Chemistry Data

TPSA 95.86
LogP 2.3591
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 5

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Threonine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-allothreonine

CAS No. 146306-75-4

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