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CS-W001157 4
Total: USD 88.00

Fmoc-Aib-OH

  • CAS No. 94744-50-0

  • Cat. No. CS-W009269
  • Purity≥98%
  • MDL No.MFCD00151913

*For research and further manufacturing use only, not for direct human use.

Fmoc-Aib-OH|CS-W009269

Structure of 94744-50-0

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General Information

  • CAS No. 94744-50-0
  • Cat. No. CS-W009269
  • Purity ≥98%
  • MDL No. MFCD00151913
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₉NO₄
  • Molecular Weight 325.36
  • Synonym(s) None
  • SMILES O=C(O)C(C)(C)NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O

Description

Fmoc-Aib-OH is a protected α-amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) group and aminoisobutyric acid (Aib) side chain. This sterically constrained residue enhances peptide backbone rigidity, facilitating the formation of stable helical structures in synthetic peptides. The Fmoc group enables efficient solid-phase peptide synthesis under mild conditions.

Synthesis

  • Route1
    • null|null
      28920-43-6
    • Aminoisobutyric acid hydrochloride|CS-0210672
      5938-34-1
    • ~84%
    • In-stock
      Fmoc-Aib-OH|CS-W009269
      94744-50-0

    References

    • Lescrinier, Theo; Hendrix, Chris; Kerremans, Luc; Rozenski, Jef; Link, Andreas; Samyn, Bart; Van Aerschot, Arthur; Lescrinier, Eveline; Eritja, Ramon; Van Beeumen, Jozef; Herdewijn, Piet Chemistry - A European Journal, 1998 , vol. 4, # 3 p. 425 - 433
  • Route2
    • null|null
      28920-43-6
    • α-Aminoisobutyric acid|CS-0229297
      62-57-7
    • ~71%
    • In-stock
      Fmoc-Aib-OH|CS-W009269
      94744-50-0

    References

    • Babu, Vommina V. Suresh; Ananda, Kuppanna Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2001 , vol. 40, # 1 p. 70 - 74
  • Route3
    • null|null
      920-66-1
    • null|null
      1072922-73-6
    • null|null
      150458-42-7
    • ~%
    • null|null
      1072922-70-3
    • null|null
      1072922-67-8
    • In-stock
      Fmoc-Aib-OH|CS-W009269
      94744-50-0

    References

    • Journal of the American Chemical Society, , vol. 130, # 44 p. 14382 - 14383

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   3.3883
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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