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CS-W001157 4
Total: USD 88.00

5-Chloro-6-methylpyrazine-2-carboxylic acid

  • CAS No. 188781-36-4

  • Cat. No. CS-0163052
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-6-methylpyrazine-2-carboxylic acid|CS-0163052

Structure of 188781-36-4

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General Information

  • CAS No. 188781-36-4
  • Cat. No. CS-0163052
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClN₂O₂
  • Molecular Weight 172.57
  • Synonym(s) None
  • SMILES O=C(C1=NC(C)=C(Cl)N=C1)O

Description

5-Chloro-6-methylpyrazine-2-carboxylic acid features a pyrazine core functionalized with chlorine, methyl, and carboxylic acid groups, offering enhanced electron-deficiency and metabolic stability. This configuration enables direct incorporation into bioactive scaffolds and pharmaceutical intermediates. The compound exhibits excellent solubility in polar organic solvents and stability under standard bench conditions.

Application

5-Chloro-6-methylpyrazine-2-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical synthesis. Its orthogonal functional groups enable direct derivatization via amide coupling, Suzuki-Miyaura cross-coupling, or nucleophilic substitution. The molecule exhibits good bench stability and facilitates purification by recrystallization, supporting scalable downstream applications in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   1.13662
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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