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CS-W001157 4
Total: USD 88.00

7-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine

  • CAS No. 882521-63-3

  • Cat. No. CS-W008673
  • Purity≥95%
  • MDL No.MFCD11846606

*For research and further manufacturing use only, not for direct human use.

7-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine|CS-W008673

Structure of 882521-63-3

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General Information

  • CAS No. 882521-63-3
  • Cat. No. CS-W008673
  • Purity ≥95%
  • MDL No. MFCD11846606
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrN₄
  • Molecular Weight 213.03
  • Synonym(s) 7-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine
  • SMILES NC1=NN2C=CC(Br)=CC2=N1

Description

7-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine is a bench-stable heterocyclic building block featuring a brominated triazolopyridine core. This nitrogen-rich scaffold integrates readily into transition metal-catalyzed coupling reactions, enabling efficient access to complex functionalized architectures in medicinal chemistry and materials science.

Application

7-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. Its bromine substituent facilitates efficient derivatization in Suzuki-Miyaura and Buchwald-Hartwig couplings, while the triazolopyridine core provides structural rigidity and enhanced solubility. The compound exhibits excellent bench stability and is readily purified by flash chromatography, making it well-suited for medicinal chemistry campaigns and API intermediate synthesis.

Synthesis

  • Route1
    • null|null
      882521-62-2
    • ~85%
    • In-stock
      7-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine|CS-W008673
      882521-63-3

    References

    • F. HOFFMANN-LA ROCHE AG; FLOHR, Alexander; GOBBI, Luca; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; PETERS, Jens-Uwe Patent: WO2012/76430 A1, 2012 ; Location in patent: Page/Page column 90 ; WO 2012/076430 A1
  • Route2

    References

    • US2012/142665 A1, ; WO2012/76430 A1, ; WO 2012/076430 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.21
  • LogP   1.074
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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