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CS-W001157 4
Total: USD 88.00

N1,N2-Bis(2-hydroxyethyl)oxalamide

  • CAS No. 1871-89-2

  • Cat. No. CS-W017412
  • Purity≥98%
  • MDL No.MFCD00020559

*For research and further manufacturing use only, not for direct human use.

N1,N2-Bis(2-hydroxyethyl)oxalamide|CS-W017412

Structure of 1871-89-2

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General Information

  • CAS No. 1871-89-2
  • Cat. No. CS-W017412
  • Purity ≥98%
  • MDL No. MFCD00020559
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂N₂O₄
  • Molecular Weight 176.17
  • Synonym(s) N,N'-Oxalylbis(ethanolamine)
  • SMILES O=C(NCCO)C(NCCO)=O

Description

Boc-Val-Ala-PAB-PNB is a cleavable peptide ADC linker. The Val-Ala will specifically be cleaved by Cathepsin B. Since this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. PNP can be substituted by amine-bearing molecules.

Synthesis

  • Route1
    • null|null
      141-43-5
    • null|null
      95-92-1
    • ~10%
    • In-stock
      N1,N2-Bis(2-hydroxyethyl)oxalamide|CS-W017412
      1871-89-2

    References

    • Elsworth, John F.; Msimang, Lorenzo N.; Jackson, Graham E. South African Journal of Chemistry, 1996 , vol. 49, # 1-2 p. 31 - 34
  • Route2
    • null|null
      95-92-1
    • ~93%
    • In-stock
      N1,N2-Bis(2-hydroxyethyl)oxalamide|CS-W017412
      1871-89-2

    References

    • LIFEGROUP S.p.A. Patent: EP550008 A2, 1993 ;
  • Route3
    • null|null
      40227-15-4
    • null|null
      141-43-5
    • ~94%
    • In-stock
      N1,N2-Bis(2-hydroxyethyl)oxalamide|CS-W017412
      1871-89-2

    References

    • Enichem Anic S.p.A. Patent: US4981963 A1, 1991 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H372-H411
Precautionary Statements : P260-P264-P270-P273-P330-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   98.66
  • LogP   -2.7966
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   4

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