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CS-W001157 4
Total: USD 88.00

3-(4-Bromophenyl)propan-1-ol

  • CAS No. 25574-11-2

  • Cat. No. CS-B0314
  • Purity≥96%
  • MDL No.MFCD09028724

*For research and further manufacturing use only, not for direct human use.

3-(4-Bromophenyl)propan-1-ol|CS-B0314

Structure of 25574-11-2

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General Information

  • CAS No. 25574-11-2
  • Cat. No. CS-B0314
  • Purity ≥96%
  • MDL No. MFCD09028724
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BrO
  • Molecular Weight 215.09
  • Synonym(s) None
  • SMILES BrC1=CC=C(C=C1)CCCO

Description

3-(4-Bromophenyl)propan-1-ol features a brominated aromatic ring linked via a flexible propylene tether to a primary alcohol. This structure enables straightforward functionalization at the terminal hydroxyl group while maintaining stability under standard reaction conditions. The para-bromophenyl moiety serves as a handle for further derivatization in synthetic and medicinal chemistry applications.

Application

3-(4-Bromophenyl)propan-1-ol serves as a versatile building block in medicinal chemistry and materials science, enabling efficient construction of biaryl and heterocyclic scaffolds. Its bromo group facilitates palladium-catalyzed cross-coupling reactions, while the primary alcohol offers orthogonal functionalization options. The compound exhibits good bench stability and ease of purification, making it well-suited for iterative synthetic workflows and scale-up applications.

Synthesis

  • Route1

    References

    • Eisai Co., Ltd. Patent: US6340759 B1, 2002 ; Location in patent: Example 299 ;
  • Route2

    References

    • Stambuli; Stauffer; Shaughnessy; Hartwig Journal of the American Chemical Society, 2001 , vol. 123, # 11 p. 2677 - 2678
  • Route3
    • 1-Allyl-4-bromobenzene|CS-0464852
      2294-43-1
    • ~44%
    • In-stock
      3-(4-Bromophenyl)propan-1-ol|CS-B0314
      25574-11-2

    References

    • ACTELION PHARMACEUTICALS LTD Patent: WO2006/61791 A2, 2006 ; Location in patent: Page/Page column 15 ; WO 2006/061791 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.374
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

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