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8-Bromooctan-1-ol

  • CAS No. 50816-19-8

  • Cat. No. CS-0015428
  • Purity≥95%
  • MDL No.MFCD00010388

*For research and further manufacturing use only, not for direct human use.

8-Bromooctan-1-ol|CS-0015428

Structure of 50816-19-8

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General Information

  • CAS No. 50816-19-8
  • Cat. No. CS-0015428
  • Purity ≥95%
  • MDL No. MFCD00010388
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₇BrO
  • Molecular Weight 209.13
  • Synonym(s) 8-Bromo-1-octanol
  • SMILES BrCCCCCCCCO

Description

8-Bromooctan-1-ol is a brominated aliphatic alcohol featuring a terminal hydroxyl group and a bromine atom at the C8 position. This structure enables efficient functionalization in nucleophilic substitution reactions, offering a versatile handle for synthesizing complex ethers and esters under mild conditions. The molecule exhibits good stability and solubility in common organic solvents, facilitating its use in synthetic workflows requiring controlled reactivity.

Application

8-Bromooctan-1-ol serves as a versatile alkyl bromide building block for nucleophilic substitution and coupling reactions. Its terminal bromide enables efficient functionalization, while the primary alcohol facilitates derivatization or protection. The molecule exhibits good bench stability and is compatible with standard reaction conditions, making it valuable for synthesizing complex organic intermediates and functionalized polymers.

Synthesis

  • Route1

    References

    • Matsumaru, Takanori; Sunazuka, Toshiaki; Hirose, Tomoyasu; Ishiyama, Aki; Namatame, Miyuki; Fukuda, Takashi; Tomoda, Hiroshi; Otoguro, Kazuhiko; Omura, Satoshi Tetrahedron, 2008 , vol. 64, # 30-31 p. 7369 - 7377
  • Route2

    References

    • Sutter, Marc; Pehlivan, Leyla; Lafon, Romain; Dayoub, Wissam; Raoul, Yann; Metay, Estelle; Lemaire, Marc Green Chemistry, 2013 , vol. 15, # 11 p. 3020 - 3026
  • Route3

    References

    • Banaszak, Estelle; Xu, Li-Wen; Bardeau, Jean-Francois; Castanet, Anne-Sophie; Mortier, Jacques Tetrahedron, 2009 , vol. 65, # 20 p. 3961 - 3966

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.7142
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   7

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