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CS-W001157 4
Total: USD 88.00

Tetraglycine

  • CAS No. 637-84-3

  • Cat. No. CS-0204513
  • Purity≥97%
  • MDL No.MFCD00008129

*For research and further manufacturing use only, not for direct human use.

Tetraglycine|CS-0204513

Structure of 637-84-3

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General Information

  • CAS No. 637-84-3
  • Cat. No. CS-0204513
  • Purity ≥97%
  • MDL No. MFCD00008129
  • Storage polypeptide, sealed storage, away from moisture and light, under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄N₄O₅
  • Molecular Weight 246.22
  • Synonym(s) None
  • SMILES O=C(O)CNC(=O)CNC(=O)CNC(=O)CN

Description

Synthesizing tetraglycine (CAS 637-84-3) via peptide coupling yields a rigid, cyclic scaffold that stabilizes β-sheet conformations in structural biology assays, enabling high-resolution X-ray crystallography of protein-ligand interfaces.

Application

Gly-Gly-Gly-Gly (CAS 637-84-3) drives peptide synthesis by serving as a critical tetramer scaffold for constructing bioactive sequences with high precision. It enhances drug delivery efficiency. Researchers leverage this stable, hydrophilic chain to probe protein folding dynamics and enzyme kinetics. This setup streamlines analytical workflows in mass spectrometry and chromatography. Its solubility profile also supports advanced cosmetic formulations targeting skin barrier recovery.

Synthesis

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    References

    • Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 153, p. 1080 Annales de Chimie (Cachan, France), , vol. <9> 3, p. 58 Annales de Chimie (Cachan, France), , vol. <9> 1, p. 544,552 Annales de Chimie (Cachan, France), , vol. <9> 2, p. 245
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      Tetraglycine|CS-0204513
      637-84-3

    References

    • Journal of the American Chemical Society, , vol. 56, p. 1179
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      Tetraglycine|CS-0204513
      637-84-3

    References

    • Russian Journal of Bioorganic Chemistry, , vol. 32, # 5 p. 420 - 428

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   150.62
  • LogP   -3.6217
  • H_Acceptors   5
  • H_Donors   5
  • Rotatable_Bonds   7

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