Imidazo[1,2-a]pyridin-8-amine

Name: Imidazo[1,2-a]pyridin-8-amine
Brand: ChemScene
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CAS No. 73221-18-8
Cat. No. CS-W019706
Purity≥95%
MDL No.MFCD06739233

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Imidazo[1,2-a]pyridin-8-amine|CS-W019706

Structure of 73221-18-8

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General Information

CAS No. 73221-18-8
Cat. No. CS-W019706
Purity ≥95%
MDL No. MFCD06739233
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇N₃
Molecular Weight 133.15
Synonym(s) IMIDAZO[1,2-A]PYRIDIN-8-YLAMINE
SMILES NC1=CC=CN2C1=NC=C2

Description

Imidazo[1,2-a]pyridin-8-amine delivers a rigid, electron-rich heterocyclic scaffold ideal for medicinal chemistry applications. This bench-stable compound features a nitrogen-rich core enabling strong hydrogen bonding and metal coordination. The pendant amine group facilitates straightforward derivatization, supporting integration into kinase inhibitors, ligands, and bioactive small molecules under standard conditions.

Application

Imidazo[1,2-a]pyridin-8-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its nitrogen-rich framework exhibits favorable hydrogen-bonding capacity and moderate basicity, enhancing solubility and target engagement. The compound functions effectively in Pd-catalyzed cross-coupling reactions and readily participates in electrophilic substitution, facilitating rapid diversification of core structures. Bench-stable and amenable to standard purification methods, it supports scalable synthesis of potential kinase inhibitors and CNS-targeted therapeutics.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 43.32
LogP 0.9165
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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Imidazo[1,2-a]pyridin-8-amine

CAS No. 73221-18-8

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