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Mal-PEG8-acid

  • CAS No. 1818294-46-0

  • Cat. No. CS-0107337
  • Purity≥98%
  • MDL No.MFCD26793771

*For research and further manufacturing use only, not for direct human use.

Mal-PEG8-acid|CS-0107337

Structure of 1818294-46-0

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General Information

  • CAS No. 1818294-46-0
  • Cat. No. CS-0107337
  • Purity ≥98%
  • MDL No. MFCD26793771
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₃₉NO₁₂
  • Molecular Weight 521.56
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCN1C(C=CC1=O)=O

Description

Mal-PEG8-acid is a maleimide-functionalized polyethylene glycol derivative featuring a C8 spacer and terminal carboxylic acid. This structure enables site-specific conjugation to thiol-containing biomolecules under physiological conditions, with the acid group facilitating further derivatization or immobilization. The PEG8 spacer provides enhanced solubility and reduced steric hindrance.

Application

Mal-PEG8-acid is a versatile bifunctional linker that combines maleimide and carboxylic acid termini with an eight-ethylene glycol unit spacer. It facilitates site-specific conjugation via Michael addition to thiols, while the terminal carboxylic acid enables amide coupling under standard conditions. The PEG8 spacer enhances solubility and reduces aggregation, making it ideal for bioconjugation applications in antibody-drug conjugates and peptide-protein labeling.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   148.52
  • LogP   -0.4811
  • H_Acceptors   11
  • H_Donors   1
  • Rotatable_Bonds   27

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