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CS-W001157 4
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Maleimido-tri(ethylene glycol)-propionic acid

  • CAS No. 518044-40-1

  • Cat. No. CS-0107746
  • Purity≥98%
  • MDL No.MFCD23103943

*For research and further manufacturing use only, not for direct human use.

Maleimido-tri(ethylene glycol)-propionic acid|CS-0107746

Structure of 518044-40-1

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General Information

  • CAS No. 518044-40-1
  • Cat. No. CS-0107746
  • Purity ≥98%
  • MDL No. MFCD23103943
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₉NO₇
  • Molecular Weight 301.29
  • Synonym(s) Mal-PEG3-acid
  • SMILES O=C(O)CCOCCOCCOCCN1C(C=CC1=O)=O

Description

Maleimido-tri(ethylene glycol)-propionic acid features a maleimide group conjugated to a tri(ethylene glycol) spacer and propionic acid terminus. This design enables efficient, site-specific bioconjugation under physiological conditions while maintaining excellent solubility and stability in aqueous environments.

Application

Maleimido-tri(ethylene glycol)-propionic acid serves as a versatile bifunctional linker for bioconjugation, combining maleimide’s selective Michael addition with thiol-containing biomolecules and a tri(ethylene glycol) spacer to enhance solubility and reduce non-specific binding. The propionic acid terminus enables further conjugation or immobilization. This reagent offers excellent bench stability, straightforward purification, and broad compatibility in antibody-drug conjugate and peptide-protein labeling workflows.

Synthesis

  • Route1
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      55750-48-6
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      1404072-05-4
    • ~%
    • In-stock
      Maleimido-tri(ethylene glycol)-propionic acid|CS-0107746
      518044-40-1

    References

    • Bayer Intellectual Property GmbH; Lerchen, Hans-Georg; Linden, Lars; El Sheikh, Sherif; Willuda, Jörg; Kopitz, Charlotte Christine; Schuhmacher, Joachim; Greven, Simone; Mahlert, Christoph; Stelte-Ludwig, Beatrix; Golfier, Sven; Beier, Rudolf; Heisler, Iring; Harrenga, Axel; Thierauch, Karl-Heinz; Bruder, Sandra; Petrul, Heike; Jörissen, Hannah; Borkowski, Sandra Patent: US2013/66055 A1, 2013 ; Location in patent: Page/Page column ; Title/Abstract Full Text Show Details Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH; Lerchen, Hans-Georg; Linden, Lars; Sheikh, Sherif El; Willuda, Jörg; Kopitz, Charlotte C.; Schuhmacher, Joachim; Greven, Simone; Mahlert, Christoph; Stelte-Ludwig, Beatrix; Golfier, Sven; Beier, Rudolf; Heisler, Iring; Harrenga, Axel; Thierauch, Karl-Heinz; Bruder, Sandra; Petrul, Heike; Jörißen, Hannah; Brokowski, Sandra Patent: US2014/127240 A1, 2014 ; Location in patent: Page/Page column ;
  • Route2

    References

    • Bayer Intellectual Property GmbH; Lerchen, Hans-Georg; Linden, Lars; El Sheikh, Sherif; Willuda, Jörg; Kopitz, Charlotte Christine; Schuhmacher, Joachim; Greven, Simone; Mahlert, Christoph; Stelte-Ludwig, Beatrix; Golfier, Sven; Beier, Rudolf; Heisler, Iring; Harrenga, Axel; Thierauch, Karl-Heinz; Bruder, Sandra; Petrul, Heike; Jörissen, Hannah; Borkowski, Sandra Patent: US2013/66055 A1, 2013 ; Title/Abstract Full Text Show Details Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH; Lerchen, Hans-Georg; Linden, Lars; Sheikh, Sherif El; Willuda, Jörg; Kopitz, Charlotte C.; Schuhmacher, Joachim; Greven, Simone; Mahlert, Christoph; Stelte-Ludwig, Beatrix; Golfier, Sven; Beier, Rudolf; Heisler, Iring; Harrenga, Axel; Thierauch, Karl-Heinz; Bruder, Sandra; Petrul, Heike; Jörißen, Hannah; Brokowski, Sandra Patent: US2014/127240 A1, 2014 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   102.37
  • LogP   -0.5641
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   12

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