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CS-W001157 4
Total: USD 88.00

Mal-PEG4-acid

  • CAS No. 518044-41-2

  • Cat. No. CS-0108929
  • Purity≥95%
  • MDL No.MFCD18916986

*For research and further manufacturing use only, not for direct human use.

Mal-PEG4-acid|CS-0108929

Structure of 518044-41-2

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General Information

  • CAS No. 518044-41-2
  • Cat. No. CS-0108929
  • Purity ≥95%
  • MDL No. MFCD18916986
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₃NO₈
  • Molecular Weight 345.35
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCOCCN1C(C=CC1=O)=O

Description

Mal-PEG4-acid features a maleimide group conjugated to a four-ether-unit polyethylene glycol chain terminating in a carboxylic acid. This structure enables site-specific bioconjugation via thiol-Michael addition, while the PEG spacer enhances solubility and reduces aggregation. The terminal acid facilitates further coupling reactions, such as amide formation, enabling modular linker design for probes, therapeutics, or biomaterials.

Application

Mal-PEG4-acid serves as a versatile bifunctional linker for conjugation and bioconjugation applications. The maleimide group enables efficient, site-specific thiol-ene addition with cysteine residues, while the terminal carboxylic acid facilitates amide coupling or further functionalization. PEG4 provides enhanced solubility and reduced aggregation, improving stability in aqueous environments. This reagent is well-suited for the synthesis of antibody-drug conjugates, protein-polymer hybrids, and targeted delivery systems.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   111.6
  • LogP   -0.5475
  • H_Acceptors   7
  • H_Donors   1
  • Rotatable_Bonds   15

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