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Azido-PEG3-NHS ester

  • CAS No. 1092654-47-1

  • Cat. No. CS-0115215
  • Purity≥95%
  • MDL No.MFCD29067172

*For research and further manufacturing use only, not for direct human use.

Azido-PEG3-NHS ester|CS-0115215

Structure of 1092654-47-1

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General Information

  • CAS No. 1092654-47-1
  • Cat. No. CS-0115215
  • Purity ≥95%
  • MDL No. MFCD29067172
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈N₄O₇
  • Molecular Weight 330.29
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)COCCOCCOCCN=[N+]=[N-]

Description

Azido-PEG3-NHS ester enables site-specific bioconjugation through orthogonal reactivity between the azide and alkyne groups. This bifunctional reagent features a hydrophilic PEG3 spacer that enhances solubility while the NHS ester facilitates efficient coupling to primary amines under physiological conditions.

Application

Azido-PEG3-NHS ester serves as a versatile bifunctional linker for bioconjugation and polymer chemistry. The NHS ester moiety readily reacts with primary amines under physiological conditions, while the terminal azide enables efficient copper-catalyzed (CuAAC) or strain-promoted (SPAAC) click reactions. Its PEG3 spacer provides enhanced solubility and reduced non-specific binding, making it ideal for labeling biomolecules, constructing functionalized surfaces, or developing targeted delivery systems with improved stability and ease of purification.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   140.13
  • LogP   -0.0463
  • H_Acceptors   8
  • H_Donors   0
  • Rotatable_Bonds   12

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