![2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride|CS-W021504](https://file.chemscene.com/productPIC/CS-W021504.gif)
Lot numbers can be found on the outside label of a product:
tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
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CAS No. 635698-56-5
- Cat. No. CS-D0280
- Purity≥97%
- MDL No.MFCD08273933
*For research and further manufacturing use only, not for direct human use.
![tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate|CS-D0280](https://file.chemscene.com/productPIC/CS-D0280.gif)
Structure of 635698-56-5
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General Information
- CAS No. 635698-56-5
- Cat. No. CS-D0280
- Purity ≥97%
- MDL No. MFCD08273933
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₁₅Cl₂N₃O₂
- Molecular Weight 304.17
- Synonym(s) 2-Methyl-2-propanyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
- SMILES O=C(N1CCC2=NC(Cl)=NC(Cl)=C2C1)OC(C)(C)C
Description
tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate is a bench-stable, moisture-tolerant heterocyclic building block featuring two chlorine substituents at electron-deficient positions. This dihydro-pyrimidine scaffold integrates readily into medicinal chemistry campaigns, enabling efficient access to kinase-inhibitor scaffolds through straightforward deprotection and functionalization.
Application
tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate serves as a versatile building block for the synthesis of pyrido[4,3-d]pyrimidine scaffolds, enabling efficient functionalization at C2 and C4 positions. Its dichloro substitution pattern facilitates sequential cross-coupling reactions and nucleophilic displacement, while the tert-butyl ester group provides stability and ease of removal under mild acidic conditions. This compound demonstrates excellent bench stability and compatibility with diverse reaction conditions, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
Synthesis
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References
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KYOWA HAKKO KOGYO CO., LTD. Patent: EP1552842 A1, 2005 ; Location in patent: Page/Page column 316 ;
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Route2
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![2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine|CS-D0513](https://file.chemscene.com/productPIC/CS-D0513.gif)
726697-13-8 -
In-stock
24424-99-5 - ~73%
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In-stock
635698-56-5
References
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ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David Patent: WO2014/15291 A1, 2014 ; Location in patent: Page/Page column 172; 173 ;
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Route3
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In-stock
![6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione|CS-D0531](https://file.chemscene.com/productPIC/CS-D0531.gif)
135481-57-1 - ~%
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In-stock
635698-56-5
References
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Journal of Medicinal Chemistry, , vol. 55, # 24 p. 10958 - 10971
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H332-H335
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Precautionary Statements : P261-P280-P338-P351
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Quality Control
Computational Chemistry Data
- TPSA 55.32
- LogP 3.0766
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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