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CS-W001157 4
Total: USD 88.00

Mal-PEG1-NHS ester

  • CAS No. 1807518-72-4

  • Cat. No. CS-0107986
  • Purity≥95%
  • MDL No.MFCD26127783

*For research and further manufacturing use only, not for direct human use.

Mal-PEG1-NHS ester|CS-0107986

Structure of 1807518-72-4

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General Information

  • CAS No. 1807518-72-4
  • Cat. No. CS-0107986
  • Purity ≥95%
  • MDL No. MFCD26127783
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₄N₂O₇
  • Molecular Weight 310.26
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCN2C(C=CC2=O)=O

Description

Mal-PEG1-NHS ester is a bifunctional crosslinker featuring a maleimide group for selective thiol conjugation and a reactive NHS ester for amine coupling. This dual functionality enables efficient site-specific bioconjugation in aqueous environments, facilitating the synthesis of antibody-drug conjugates and peptide-protein hybrids under mild conditions.

Application

Mal-PEG1-NHS ester serves as a versatile bifunctional linker for site-specific conjugation, combining the reactive NHS ester with a maleimide group. It enables efficient coupling to primary amines under physiological conditions, followed by rapid, selective Michael addition with thiols. Ideal for antibody-drug conjugates and bioconjugation workflows, it offers excellent stability in aqueous media and simplifies purification due to minimal side reactions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   110.29
  • LogP   -1.0747
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   7

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