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CS-W001157 4
Total: USD 88.00

N3-PEG3-CH2COOH

  • CAS No. 172531-37-2

  • Cat. No. CS-0025201
  • Purity≥95%
  • MDL No.MFCD16295189

*For research and further manufacturing use only, not for direct human use.

N3-PEG3-CH2COOH|CS-0025201

Structure of 172531-37-2

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General Information

  • CAS No. 172531-37-2
  • Cat. No. CS-0025201
  • Purity ≥95%
  • MDL No. MFCD16295189
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅N₃O₅
  • Molecular Weight 233.22
  • Synonym(s) PROTAC Linker 14
  • SMILES OC(COCCOCCOCCN=[N+]=[N-])=O

Description

N3-PEG3-CH2COOH is a trifunctional linker featuring a terminal azide, a three-unit polyethylene glycol spacer, and a carboxylic acid handle. This combination enables efficient bioconjugation via strain-promoted or copper-catalyzed azide-alkyne cycloaddition, while the PEG3 segment imparts solubility and reduces non-specific binding in aqueous environments. The carboxylic acid facilitates conjugation to amine-functionalized biomolecules through standard coupling chemistries.

Synthesis

  • Route1
    • In-stock
      Azido-PEG3-alcohol|CS-W017451
      86520-52-7
    • null|null
      79-08-3
    • ~76%
    • In-stock
      N3-PEG3-CH2COOH|CS-0025201
      172531-37-2

    References

    • Sang Won Jeong; O'Brien Journal of Organic Chemistry, 2001 , vol. 66, # 14 p. 4799 - 4802
  • Route2

    References

    • Liao, Longyan; Liu, Jenny; Dreaden, Erik C.; Morton, Stephen W.; Shopsowitz, Kevin E.; Hammond, Paula T.; Johnson, Jeremiah A. Journal of the American Chemical Society, 2014 , vol. 136, # 16 p. 5896 - 5899
  • Route3
    • null|null
      79-08-3
    • ~66%
    • In-stock
      N3-PEG3-CH2COOH|CS-0025201
      172531-37-2

    References

    • NOVO NORDISK A/S Patent: WO2006/87354 A2, 2006 ; Location in patent: Page/Page column 84 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   113.75
  • LogP   0.4311
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   11

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