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CS-W001157 4
Total: USD 88.00

Azido-PEG2-CH2COOH

  • CAS No. 882518-90-3

  • Cat. No. CS-0028491
  • Purity≥97%
  • MDL No.MFCD24395877

*For research and further manufacturing use only, not for direct human use.

Azido-PEG2-CH2COOH|CS-0028491

Structure of 882518-90-3

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General Information

  • CAS No. 882518-90-3
  • Cat. No. CS-0028491
  • Purity ≥97%
  • MDL No. MFCD24395877
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁N₃O₄
  • Molecular Weight 189.17
  • Synonym(s) None
  • SMILES O=C(O)COCCOCCN=[N+]=[N-]

Description

Azido-PEG2-CH2COOH is a bifunctional linker featuring a reactive azide group and a carboxylic acid handle, enabling site-specific conjugation in bioorthogonal chemistry. The short PEG spacer provides enhanced solubility and controlled spacing, while the terminal COOH facilitates coupling to amine-containing biomolecules under standard activation conditions.

Application

Azido-PEG2-CH2COOH serves as a versatile bifunctional building block for conjugation and macrocyclization strategies. The azide group enables reliable copper-catalyzed or strain-promoted click reactions, while the terminal carboxylic acid facilitates amide coupling under standard conditions. The PEG2 spacer provides enhanced solubility and reduced aggregation, improving handling and reaction efficiency in aqueous environments. This reagent functions reliably in peptide modification, probe synthesis, and polymer-based drug delivery systems.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   104.52
  • LogP   0.4145
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   8

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