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Azido-PEG5-CH2CO2H

  • CAS No. 217180-81-9

  • Cat. No. CS-0105535
  • Purity≥97%
  • MDL No.MFCD31561141

*For research and further manufacturing use only, not for direct human use.

Azido-PEG5-CH2CO2H|CS-0105535

Structure of 217180-81-9

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General Information

  • CAS No. 217180-81-9
  • Cat. No. CS-0105535
  • Purity ≥97%
  • MDL No. MFCD31561141
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₃N₃O₇
  • Molecular Weight 321.33
  • Synonym(s) None
  • SMILES O=C(O)COCCOCCOCCOCCOCCN=[N+]=[N-]

Description

Azido-PEG5-CH2CO2H features a terminal azide group linked via a five-ethylene glycol spacer to a carboxylic acid moiety. This bifunctional construct enables site-specific conjugation through strain-promoted or copper-catalyzed azide-alkyne cycloaddition, while the carboxylate facilitates amide bond formation. The PEG chain imparts solubility and reduces non-specific binding in biological systems.

Application

Azido-PEG5-CH2CO2H serves as a versatile bifunctional building block for bioconjugation and polymer chemistry, combining the robustness of a PEG spacer with orthogonal functional groups. The terminal azide enables efficient strain-promoted or copper-catalyzed cycloaddition (SPAAC/CuAAC), while the carboxylic acid facilitates amide coupling under standard conditions. Its well-defined structure ensures reproducible conjugation outcomes, and the PEG5 chain enhances solubility and reduces non-specific binding in biological applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   132.21
  • LogP   0.4643
  • H_Acceptors   7
  • H_Donors   1
  • Rotatable_Bonds   17

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