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Azido-PEG3-alcohol

  • CAS No. 86520-52-7

  • Cat. No. CS-W017451
  • Purity≥96%
  • MDL No.MFCD09753542

*For research and further manufacturing use only, not for direct human use.

Azido-PEG3-alcohol|CS-W017451

Structure of 86520-52-7

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General Information

  • CAS No. 86520-52-7
  • Cat. No. CS-W017451
  • Purity ≥96%
  • MDL No. MFCD09753542
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃N₃O₃
  • Molecular Weight 175.19
  • Synonym(s) None
  • SMILES [N-]=[N+]=NCCOCCOCCO

Description

4-Nitrophenyl decanoate has been used as a substrate for assessing the lipase activity spectrophotometrically. It has also been used as a substrate for estimating the carboxylesterases activity.

Application

Azido-PEG3-alcohol serves as a versatile bifunctional building block for bioconjugation and polymer chemistry. The terminal azide group enables reliable copper-catalyzed [3+2] cycloaddition (CuAAC), while the primary alcohol facilitates derivatization or chain extension. Its PEG3 spacer provides solubility and reduced non-specific binding, enhancing performance in aqueous environments. Ideal for synthesizing responsive linkers, functionalized nanoparticles, or site-specific protein conjugates with excellent stability and ease of purification.

Synthesis

  • Route1

    References

    • Uppal, Timsy; Bhupathiraju, N.V.S. Dinesh K.; Vicente, M. Graca H. Tetrahedron, 2013 , vol. 69, # 23 p. 4687 - 4693
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    References

    • Lam, Son N.; Acharya, Priyamvada; Wyatt, Richard; Kwong, Peter D.; Bewley, Carole A. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10113 - 10120
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    References

    • Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 2398
Class : 3
Packing Group : Ⅱ
Hazard Statements : H225-H315
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P302+P352-P362+P364-P370+P378-P501

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Computational Chemistry Data

  • TPSA   87.45
  • LogP   0.3222
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   8

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