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CS-W001157 4
Total: USD 88.00

Boc-Lys(Tfa)-OH

  • CAS No. 16965-06-3

  • Cat. No. CS-0128331
  • Purity≥98%
  • MDL No.MFCD00037104

*For research and further manufacturing use only, not for direct human use.

Boc-Lys(Tfa)-OH|CS-0128331

Structure of 16965-06-3

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General Information

  • CAS No. 16965-06-3
  • Cat. No. CS-0128331
  • Purity ≥98%
  • MDL No. MFCD00037104
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₁F₃N₂O₅
  • Molecular Weight 342.31
  • Synonym(s) (S)-2-((tert-Butoxycarbonyl)amino)-6-(2,2,2-trifluoroacetamido)hexanoic acid
  • SMILES O=C(O)[C@@H](NC(OC(C)(C)C)=O)CCCCNC(C(F)(F)F)=O

Description

Boc-Lys(Tfa)-OH features a tert-butyl carbamate-protected lysine side chain, enabling selective peptide coupling under mild conditions. The trifluoroacetyl group enhances solubility and stability during synthesis, while the Boc moiety ensures efficient deprotection without side reactions. This derivative supports robust N-terminal protection in complex peptide sequences.

Application

Boc-Lys(Tfa)-OH serves as a protected lysine building block for peptide synthesis, offering enhanced solubility and stability in aqueous and organic media. The TFA-protected side chain prevents undesired backbone cyclization, while the Boc group enables orthogonal deprotection under mild acidic conditions. This derivative facilitates efficient coupling reactions and simplifies purification, making it ideal for constructing complex peptide sequences and peptidomimetics in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   104.73
  • LogP   1.8131
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   7

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