Lot numbers can be found on the outside label of a product:
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid
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CAS No. 1202003-49-3
- Cat. No. CS-0101052
- Purity≥97%
- MDL No.MFCD17019258
*For research and further manufacturing use only, not for direct human use.
Structure of 1202003-49-3
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General Information
- CAS No. 1202003-49-3
- Cat. No. CS-0101052
- Purity ≥97%
- MDL No. MFCD17019258
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₂₇H₃₄N₂O₆
- Molecular Weight 482.57
- Synonym(s) N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-methyl-L-lysine
- SMILES O=C(O)[C@@](CCCCNC(OC(C)(C)C)=O)(C)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
Description
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid features a sterically hindered aliphatic chain flanked by orthogonal protecting groups: the Fmoc moiety at the α-amino position and a Boc group at the ε-amino site. This configuration enables selective deprotection during peptide synthesis, facilitating efficient incorporation of hydrophobic, branched amino acid residues into complex sequences under standard conditions.
Application
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid serves as a versatile chiral building block for peptide synthesis, enabling efficient N-terminal protection and side-chain functionalization. The Fmoc group facilitates orthogonal deprotection under mild basic conditions, while the Boc-protected lysine-like side chain allows for selective modification. Its bench-stable nature and compatibility with standard coupling reagents make it ideal for solid-phase and solution-phase peptide assembly workflows.
Synthesis
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Route1
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In-stock
24424-99-5 -
1453178-51-2 - ~94%
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In-stock
1202003-49-3
References
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Banerjee, Souvik; Wiggins, Walker J.; Geoghegan, Jessie L.; Anthony, Catherine T.; Woltering, Eugene A.; Masterson, Douglas S. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 37 p. 6307 - 6319
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References
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Chauhan, Satendra S. Tetrahedron Letters, 2009 , vol. 50, # 49 p. 6913 - 6915
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Route3
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17377-68-3
- ~%
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In-stock
1202003-49-3
References
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Banerjee, Souvik; Wiggins, Walker J.; Geoghegan, Jessie L.; Anthony, Catherine T.; Woltering, Eugene A.; Masterson, Douglas S. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 37 p. 6307 - 6319
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 113.96
- LogP 5.0634
- H_Acceptors 5
- H_Donors 3
- Rotatable_Bonds 9
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Key Words
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