Fmoc-L-Hgn(Trt)-OH

Name: Fmoc-L-Hgn(Trt)-OH
Brand: ChemScene
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CAS No. 1263046-43-0
Cat. No. CS-0087324
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1263046-43-0
Cat. No. CS-0087324
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₀H₃₆N₂O₅
Molecular Weight 624.72
Synonym(s) Fmoc-L-β-Homo-Gln(Trt)-OH
SMILES O=C(O)[C@H](CCCC(NC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O)NC(OCC4C5=C(C6=C4C=CC=C6)C=CC=C5)=O

Description

Fmoc-L-Hgn(Trt)-OH is a protected amino acid derivative featuring a trifluoromethylated guanidine side chain, designed for efficient incorporation into peptide sequences. The Fmoc group enables orthogonal protection during solid-phase synthesis, while the Trt-labile guanidine moiety allows selective deprotection under mild acidic conditions. This compound delivers high coupling efficiency and stability in standard synthetic workflows.

Application

Fmoc-L-Hgn(Trt)-OH serves as a protected amino acid building block for solid-phase peptide synthesis, featuring a trifluoromethylsulfonyl (Trt)-protected guanidine side chain. The Fmoc group enables orthogonal deprotection under mild basic conditions, while the Trt moiety ensures stability during acidic cleavage steps. This derivative facilitates the incorporation of arginine mimics into peptide sequences with high fidelity and ease of purification.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 104.73
LogP 7.2569
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 12

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-L-Hgn(Trt)-OH

CAS No. 1263046-43-0

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